US Secretary of State John Kerry is in Russia to try to bridge the divide with Washington over the Syria conflict.
He is to have talks with President Vladimir Putin in Moscow but the two disagree on the future of President Bashar al-Assad.
Russia, which supports Mr Assad, refuses to back US pressure designed to force him to step down.
The US recently said it does not rule out providing arms for the Syrian opposition.
“Arming the rebels – that’s an option,” US Defence Secretary, Chuck Hagel said last week.
Mr Kerry’s visit comes days after Israel launched air strikes in southern Syria.
Russia condemned the attacks – which Israeli sources said targeted missiles destined for Hezbollah in Lebanon – as a threat to regional stability.
President Putin had spoken to Israeli Prime Minister Benjamin Netanyahu, the Kremlin said.
Chemical weapons
Ahead of Mr Kerry’s visit, Russia’s foreign ministry called on the West to stop politicising the issue of chemical weapons in Syria, BBC Moscow correspondent Steven Rosenberg reports.
It expressed concern that world public opinion was being prepared for possible military intervention, he adds.
The United Nations has played down claims by one of its experts that there was evidence rebels had used nerve gas.
Investigator Carla Del Ponte earlier said testimony from victims and doctors had given rise to “strong, concrete suspicions but not yet incontrovertible proof” that opposition forces had used sarin.
But the Commission of Inquiry on Syria stressed on Monday it had not reached any “conclusive findings”.
The colourless, odourless gas is classed as a weapon of mass destruction and is banned under international law.
In Washington, White House spokesman Jay Carney said it was “highly likely” that any use of chemical weapons that had taken place had been carried out by government forces.
Both the US and Israel have described the use of chemical weapons in the Syrian conflict as a “game-changer”, which could trigger international military intervention.
‘Particular alarm’
Correspondents say it is unlikely that Mr Kerry will be able to change President Putin’s stance on Syria.
Moscow genuinely fears that a bad situation will get even worse if President Bashar al-Assad is pushed from power, and that Islamists will fill the void, reports the BBC’s Steven Rosenberg in Moscow.
Officials said Israel’s air strikes on Syrian army bases at the weekend had “caused particular alarm”.
Unconfirmed reports from activists said as many as 42 soldiers had been killed in the attacks near Damascus.
“The further escalation of armed confrontation sharply increases the risk of creating new areas of tension and the destabilisation of the so-far relatively calm atmosphere on the Lebanese-Israeli border,” Russia’s foreign ministry said in a statement.
Israeli security sources said attacks on targets in southern Syria on Sunday were aimed at preventing the transfer of advanced Iranian-made missiles to the Shia Islamist movement, Hezbollah, in neighbouring Lebanon.
But observers say the latest developments indicate a significant escalation in Israel’s involvement in the conflict.
The Syrian government called the attacks a “flagrant violation of international law”, which had made the Middle East “more dangerous” and opened “the door wide to all possibilities”.
After his visit to Russia, Mr Kerry will travel to Rome to meet Italian, Israeli and Jordanian officials to discuss Middle East issues, including the Palestinian-Israeli peace process.